Welcome, everyone! I hope life has been treating you well. My name is Alvaro, and today we're diving into a new technology for treating aortic disease: the AMDS Hybrid Prosthesis. This prosthesis is designed by Artivion to treat acute DeBakey Type I aortic dissection. Today the standard of care is an ascending replacement or hemiarch repair. While this procedure can successfully remove the primary entry tear, it fails to adequately address the remainder of
the diseased aorta, here's where this new technology enters into the game.
What is an AMDS Hybrid Prosthesis and how does it work?
Imagine the aorta as a large water pipe that suddenly develops a major crack—a scenario that, in the human body, is known as an aortic dissection. For now, we'll focus on one specific type: DeBakey Type I. This type of dissection is particularly dangerous because it involves a tear that splits the aorta into two channels: the true lumen (the main passageway for blood) and the false lumen (an unintended, problematic channel). Left untreated, this “cracked pipe” can lead to rapid and catastrophic failure, much like a leaking water pipe that could burst if not properly repaired.
Now, consider the standard surgical repair known as a hemiarch repair. In our analogy, this is like patching only part of the cracked pipe—the damaged section closest to the visible break is fixed, much like applying an external patch to stop the immediate leak. However, while the patch might stop the obvious leak, it often leaves the remainder of the pipe vulnerable. In medical terms, this standard repair can inadvertently create a new weak spot at the site where the patch ends, a phenomenon known as a distal anastomotic new entry tear (DANE). This new tear can allow water (or blood) to continue leaking into the false channel, much like a poorly sealed patch might eventually allow leaks to reoccur.
The AMDS™ Hybrid Prosthesis is a specialized device designed to treat acute DeBakey Type I aortic dissection by reinforcing the entire affected aortic segment from the inside, much like an internal liner for a cracked pipe. It not only repairs the initial tear but also prevents the formation of new leaks by expanding the true lumen, reducing the false lumen, and stabilizing the overall aortic diameter. This comprehensive support restores proper blood flow and minimizes the risk of future complications, offering a more durable solution compared to traditional hemiarch repairs.
What does AMDS Hybrid Prosthesis treat?
It’s design to treat and Improve outcomes in patients with Acute DeBakey I Dissections
Is it in all hospitals ?
This innovation emerged following the PERSEVERE trial, which evaluated whether the AMDS Hybrid Prosthesis could safely and effectively treat patients with acute DeBakey Type I aortic dissection. The FDA granted premarket approval at select centers, and some hospitals, including UF Health Jacksonville, received humanitarian device exemptions.
What happens during AMDS Hybrid Prosthesis ?
A preoperative CT scan is made
A cut through the chest is made and the aorta is expose
A tube is inserted to the aorta and this is gilded until the part of the cuff on place
A Conventional surgical repair is made to the Cuff and the chest is close
More details: Ascyrus Medical Dissection Stent(AMDS) Animation
Why is this important for the future?
Clinical results from studies such as the DARTS study and PERSEVERE trial show that the AMDS™ Hybrid Prosthesis works very well in patients with acute aortic dissection. It helps stop new tears from forming and improves blood flow by quickly expanding the true channel inside the aorta—this takes only about 3 minutes during surgery. As a result, patients experience fewer complications, with no new leaks seen in studies and most issues like poor blood flow resolved, making it a safer and more reliable option compared to traditional repairs.
This is all we have for you today folks. We hope this has been informative and we will continue reporting you guys on this. Join us back here next Tuesday
ATT
ALVARO JOSE MARTINEZ SANTACRUZ
Bibliography
[1] AMDSTM hybrid prosthesis. Artivion 2024. https://artivion.com/product/amds-hybrid-prosthesis/ (accessed March 24, 2025).
[2] Montagner M, Heck R, Kofler M, Buz S, Starck C, Sündermann S, et al. New hybrid prosthesis for acute type A aortic dissection. Surg Technol Int 2020;36:95–7.
[3] Clinicaltrials.gov. Clinicaltrials.gov n.d. https://www.clinicaltrials.gov/study/NCT05174767 (accessed March 24, 2025).
[4] Macdonald D. New heart device in use at UF Health Jacksonville. Jacksonville Daily Record 2025.
[5] Bozso SJ, Nagendran J, Chu MWA, Kiaii B, El-Hamamsy I, Ouzounian M, et al. Three-year outcomes of the Dissected Aorta Repair Through Stent Implantation trial. J Thorac Cardiovasc Surg 2024;167:1661-1669.e3. https://doi.org/10.1016/j.jtcvs.2022.08.040.
[6] Szeto WY, Fukuhara S, Fleischman F, Sultan I, Brinkman W, Arnaoutakis G, et al. A novel hybrid prosthesis for open repair of acute DeBakey type I dissection with malperfusion: Early results from the PERSEVERE trial. J Thorac Cardiovasc Surg 2024. https://doi.org/10.1016/j.jtcvs.2024.07.059.
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