Happy Monday! This week we're continuing our Medication Spotlight with Angiotensin-Converting Enzyme Inhibitors (ACE inhibitors).
Medication Spotlight 2: ACE Inhibitors
What Are ACE Inhibitors?
ACE inhibitors, or Angiotensin-Converting Enzyme inhibitors, are a class of drugs commonly prescribed to manage high blood pressure (hypertension) and heart conditions. In patients with aortic disease controlling blood pressure is critical to preventing further damage to the aorta. High blood pressure increases the force exerted on the walls of the aorta which significantly raises the risk of rupture. By lowering blood pressure, ACE inhibitors help to stabilize and minimize the strain on the aorta.
How Do ACE Inhibitors Work?
ACE inhibitors work by blocking the enzyme that converts angiotensin I to angiotensin II, a substance in the body that causes blood vessels to narrow. When angiotensin II is reduced, blood vessels relax and widen, allowing blood to flow more easily. This leads to a decrease in blood pressure, which reduces the amount of force the heart needs to pump blood through the aorta.
For patients with aortic disease, lowering blood pressure with ACE inhibitors is vital because it helps slow down the progression of aneurysms and reduces the risk of dissection. Also, ACE inhibitors improve heart function! This is helpful in patients whose aortic disease is accompanied by heart failure or other cardiovascular issues.
Common ACE Inhibitors
Some of the most frequently prescribed ACE inhibitors for managing aortic disease include:
Lisinopril
Enalapril
Ramipril
More Benefits of ACE Inhibitors!
Studies suggest that ACE inhibitors can reduce inflammation and improve the structure of blood vessels over time, which may help prevent the development or progression of aneurysms. For patients with conditions like bicuspid aortic valve disease, ACE inhibitors are used to prevent excessive aortic dilation.
Long-Term Use
Just like beta-blockers (spoken about in our first Medication Spotlight post), ACE inhibitors are often a long-term treatment for patients with aortic disease. Regular monitoring by healthcare providers is important to ensure that the medication is effectively controlling blood pressure and preventing complications. Patients on ACE inhibitors may also undergo routine blood tests to check kidney function and electrolyte levels, as these medications can affect both. If you or a loved one has been prescribed ACE inhibitors for aortic disease, it’s crucial to take them as prescribed and work closely with your healthcare team to monitor your condition.
Always consult your doctor to understand the best treatment strategy for your unique situation.
Thanks for joining us this week, Aortic Hope family! Stay tuned for our next Medication Spotlight post in two weeks.
Always a pleasure,
Samantha
Excellent article. Very good information.